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 A large European study links daily aspirin use to increased risk of age-related macular degeneration (AMD), a disease that can damage the central vision that is essential for reading, driving, and navigating daily life. The study found that people aged 65 and older who took aspirin daily had double the risk of developing "wet" AMD, compared with those who took it less frequently.
Wet AMD, an advanced form of the disease, is a major cause of blindness in older people in the United States, Europe and other regions. The damage occurs when abnormal blood vessels grow and bleed or leak fluid into the macula, the center of eye's retina. The study also found a somewhat elevated risk of early-stage AMD in daily aspirin users. No higher risk was found for advanced "dry" AMD. Although dry AMD is the most common form of the disease, only a minority of patients develop the advanced stage. In those who do, vision loss occurs gradually as the macula develops abnormal deposits called drusen and eventually becomes too thin and eroded to function.
Because aspirin can reduce pain, inflammation and blood clots, many doctors recommend it to patients with cardiovascular disease. Those with heart disease are therefore more likely than the average person to take daily aspirin. In this study, the 839 participants who reported taking aspirin every day had higher rates of cardiovascular disease, were less likely to be smokers, and were older than participants who took aspirin less often. Since cardiovascular disease itself is a risk factor for AMD, the researchers carefully analyzed whether participants' heart health had impacted the study's outcomes. But even when cardiovascular status was factored in, the results showed higher risk for wet AMD in daily aspirin users.
The researchers say they think medical professionals should stick with their current advice on aspirin for older, cardiovascular disease patients, until other studies confirm the link between daily aspirin use and wet AMD risk.
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